MitochondrialResearch OnlyB

MOTS-c

Mitochondrial ORF of 12S rRNA type-c

MOTS-c is a 16-amino acid mitochondria-derived peptide (MDP) encoded within the 12S rRNA region of the mitochondrial genome — one of only a few proteins known to be encoded by mitochondrial DNA. Early human studies and animal research show it activates AMPK signaling, improves insulin sensitivity, enhances exercise capacity, and reduces age-related metabolic decline. Research only.

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Observational report only — live community data. Not medical advice. Does not recommend doses, protocols, or treatments.
Studies cited
8
Research grade
B
Experience
27

Overall check-ins

Activity
40

Trackers & reports

Overview

About MOTS-c

MOTS-c is a 16-amino acid mitochondria-derived peptide (MDP) encoded within the 12S rRNA region of the mitochondrial genome — one of only a few proteins known to be encoded by mitochondrial DNA. Early human studies and animal research show it activates AMPK signaling, improves insulin sensitivity, enhances exercise capacity, and reduces age-related metabolic decline. Research only.

Category
Mitochondrial
Regulatory status
Research Only
Also known as
Mitochondrial ORF of 12S rRNA type-c
Self-reports
113

Community

What 113 users report

113 community reports

Overall experience

From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.

Favorable 18% · Mixed 2% · Unfavorable overall 80%

Most reported benefits

Benefits users selected when logging a favorable or mixed check-in.

Appetite
230
Energy
47
Recovery
3
Mood
2
Cognition
1

Most logged side effects

Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.

Injection site irritation
191

Self-reported dose per injection

Median bucket: 2–3 mg · Most common: 5+ mg

Reports span 0.01 to ≥ 5 mg (open-ended top bucket)

0.01–0.025 mg
4
0.1–0.2 mg
1
0.2–0.4 mg
8
0.4–0.6 mg
11
0.6–1 mg
8
1–2 mg
42
2–3 mg
45
3–5 mg
7
5+ mg
107

Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.

How repeat users are trending

Among repeat reporters, 56% said they felt similar to their last entry, 31% more positive, and 13% more negative.

Overall, repeat reporters leaned more positive than their previous entry.

Median gap between entries: 44 days · Based on 45 repeat reporters

Research

Cited research (6)

PubMed

MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism

Lee et al., 2016

Source
Wiki study page →

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Help

Frequently asked

What do PeptIQ users report about MOTS-c?

This page summarizes 113 anonymized self-reports from PeptIQ users who track MOTS-c, including commonly reported effects and co-tracked peptides. These are observational patterns, not clinical outcomes.

How do side effects relate to overall experience for MOTS-c?

PeptIQ separates overall check-in ratings (favorable, mixed, or unfavorable) from logged side effects like nausea or fatigue. Users often report benefits and side effects in the same check-in — a high experience score does not mean zero side effects were noted.

What research is cited for MOTS-c?

6 sources are linked on this page, including PubMed articles, clinical trial registries, and FDA labels where applicable. Citations describe published research — not recommendations.

Is MOTS-c safe to use?

This wiki does not assess safety or recommend use. MOTS-c is listed as Research Only. Consult a licensed clinician for personal medical decisions.

What are the purported benefits and uses of MOTS-c?

This wiki summarizes observational community reports and linked citations for MOTS-c. It does not assert therapeutic benefits. See the cited research list on this page and the educational profile for MOTS-c for study-level context — not medical advice.

What is the legal status of MOTS-c?

MOTS-c is listed in PeptIQ as Research Only. Regulatory status varies by jurisdiction and can change. This wiki does not provide legal advice; check current FDA and local rules and talk with a licensed clinician or counsel for personal decisions.

What are the known or theoretical side effects and risks of MOTS-c?

Safety data quality for MOTS-c varies widely by compound and study design. PeptIQ does not establish a risk profile here. Review primary literature, product labeling where applicable, and clinician guidance. Community self-reports are not a substitute for clinical evidence.

What is the current state of research on MOTS-c?

This page links 6 indexed sources for MOTS-c. Evidence maturity differs by application — some peptides have large human programs, others are mostly preclinical. Treat citation counts as literature volume, not proof of efficacy.