Longevity & Anti-AgingSupplement / Clinical UseS

NAD+

Nicotinamide Adenine Dinucleotide

Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme present in all living cells, central to energy metabolism (cellular respiration), DNA repair, and sirtuins-mediated gene expression regulation. NAD+ levels decline significantly with aging. IV and subcutaneous NAD+ infusion clinics have grown substantially for anti-aging, metabolic health, cognitive support, and addiction recovery. Oral precursors (NMN, NR) are widely available as supplements.

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Observational report only — live community data. Not medical advice. Does not recommend doses, protocols, or treatments.
Studies cited
5
Research grade
S
Community score
175

Trend index

Trackers
3,337

Overview

About NAD+

Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme present in all living cells, central to energy metabolism (cellular respiration), DNA repair, and sirtuins-mediated gene expression regulation. NAD+ levels decline significantly with aging. IV and subcutaneous NAD+ infusion clinics have grown substantially for anti-aging, metabolic health, cognitive support, and addiction recovery. Oral precursors (NMN, NR) are widely available as supplements.

Category
Longevity & Anti-Aging
Regulatory status
Supplement / Clinical Use
Also known as
Nicotinamide Adenine Dinucleotide
Self-reports
96

Community

What 96 users report

96 community reports

Positive 2% · Neutral 98% · Negative 0%

Most reported benefits

Energy
197
Appetite
197

Most reported side effects

Headache
66
Nausea
64
Injection site irritation
64

Dose distribution

Median: 2000+ mcg · Most common: 2000+ mcg

0–25
0
25–50
0
50–100
0
100–200
2
200–400
17
400–600
8
600–1000
1
1000–2000
2
2000+
167

How repeat users are trending

Among repeat reporters, 95% said they felt similar to their last entry, 5% more positive, and 0% more negative.

Overall, repeat reporters leaned more positive than their previous entry.

Median gap between entries: 51 days · Based on 42 repeat reporters

Research

Cited research (3)

Help

Frequently asked

What do PeptIQ users report about NAD+?

This page summarizes 96 anonymized self-reports from PeptIQ users who track NAD+, including commonly reported effects and co-tracked peptides. These are observational patterns, not clinical outcomes.

What research is cited for NAD+?

3 sources are linked on this page, including PubMed articles, clinical trial registries, and FDA labels where applicable. Citations describe published research — not recommendations.

Is NAD+ safe to use?

This wiki does not assess safety or recommend use. NAD+ is listed as Supplement / Clinical Use. Consult a licensed clinician for personal medical decisions.

What are the purported benefits and uses of NAD+?

Research, primarily in animal models, suggests NAD+ may have a wide range of therapeutic potentials due to its ability to promote angiogenesis (formation of new blood vessels), stimulate collagen synthesis, and modulate inflammatory responses.

Source

What is the legal status of NAD+?

NAD+ is not approved by the FDA for any human use. There is no legal basis for selling it as a drug, food, or dietary supplement in the United States. The FDA has classified NAD+ as a Category 2 bulk drug substance, which explicitly prohibits licensed compounding pharmacies from using it in compounded medications.

Source

What are the known or theoretical side effects and risks of NAD+?

The safety and effectiveness of NAD+ have not been thoroughly evaluated in humans through rigorous clinical trials. This lack of human data means that safe dosages, short-term side effects, and long-term health consequences are largely unknown.

Source

What is the current state of research on NAD+?

While there are over 200 published studies on NAD+, the vast majority are animal or in vitro (cell) studies. These preclinical studies consistently show positive results across various tissue types. However, there is a significant lack of comprehensive human clinical trial data.

Source