What is GHK-Cu?
GHK-Cu (glycyl-L-histidyl-L-lysine copper) is a naturally occurring tripeptide found in human plasma, saliva, and urine with a high affinity for copper ions. Widely used in dermatology, it has demonstrated the ability to stimulate collagen and elastin synthesis, promote wound healing, activate antioxidant enzymes, and reduce inflammatory skin damage. Commercially available OTC in cosmetic serums, creams, and injectable formulations.
Mechanism of Action
Copper chelation enabling cuproenzyme activity; upregulates collagen I, III, elastin, and glycosaminoglycans; activates TGF-β and VEGF pathways; reduces oxidative stress via SOD and catalase induction
Target: Copper-dependent enzymes, TGF-β receptor, ECM proteins
Research Indications
Supports collagen synthesis and skin barrier function
Research shows potential for reducing fine lines and improving skin texture
May accelerate cutaneous wound healing
Research Protocols
These are commonly discussed research protocols — not medical advice. Consult a healthcare provider before use.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Starting Dose | Low dose | Per protocol | Varies |
| Standard Dose | Titrated | Per protocol | Varies |
Peptide & Drug Interactions
Always consult your healthcare provider before combining with other compounds. Use our Interaction Checker for reference.
How to Apply
- 1
Ensure hands and work area are clean before handling any peptide product
- 2
Topical GHK-Cu products are typically pre-formulated — follow product instructions
- 3
Apply a thin layer to clean, dry skin in the target area
- 4
Store as directed on packaging, typically at room temperature away from direct sunlight
- 5
Avoid applying to broken or irritated skin unless directed by a provider
What to Expect
Week 1–2
Initial effects and adaptation period. Monitor for any adverse reactions.
Week 2–4
Primary effects begin to manifest. Adjust dosing as recommended by your provider.
Week 4–8
Main therapeutic effects should be established. Assess progress with your provider.
Week 8+
Evaluate results and determine continuation, cycling, or dose adjustments.
Side Effects & Safety
- Injection site reactions (redness, bruising, mild pain)
- Potential for allergic reaction — discontinue if rash or hives occur
- Individual reactions vary — start at the lowest dose and monitor carefully
- Consult your healthcare provider before use and report any unusual symptoms
FDA Status & Regulatory Info
GHK-Cu (glycyl-L-histidyl-L-lysine copper) is a naturally occurring tripeptide found in human plasma, saliva, and urine with a high affinity for copper ions. Widely used in dermatology, it has demonstrated the ability to stimulate collagen and elastin synthesis, promote wound healing, activate antioxidant enzymes, and reduce inflammatory skin damage. Commercially available OTC in cosmetic serums, creams, and injectable formulations.
Frequently Asked Questions
Research References
External links for education only. We do not control third-party content.
Community-reported data
The information below reflects self-reported experiences from PeptIQ app users. It is not clinical evidence and should not replace professional medical advice.
Community Intelligence
What 119 users report
Positive 2% · Neutral 98% · Negative 0%
Most reported benefits
Most reported side effects
Dose distribution
Median: 2000+ mcg · Most common: 2000+ mcg
Commonly stacked with
How repeat users are trending
Among repeat reporters, 91% said they felt similar to their last entry, 9% more positive, and 0% more negative.
Overall, repeat reporters leaned more positive than their previous entry.
Median gap between entries: 46 days · Based on 45 repeat reporters
Share Your Experience
Rate GHK-Cu in the PeptIQ app and help the community make informed decisions.
Research purposes only
This page is for educational reference. It is not medical or legal advice. Consult the FDA and a licensed healthcare professional for current regulations and individualized guidance.