PubMed
Melanotan II and its molecular mechanisms
Dorr et al., 2009
Sexual Health⚠️ Not Approved — CautionC
Melanotan II
MT-II
Melanotan II (MT-II) is a synthetic analog of α-melanocyte-stimulating hormone (α-MSH) studied for skin tanning, erectile function, and appetite suppression. Not FDA-approved and associated with significant safety concerns including dangerous nausea, uncontrolled melanocytic changes (nevi/moles), hypertension, and priapism. The FDA has issued multiple warnings. Banned from 503A compounding. Use with extreme caution.
Observational report only — live community data. Not medical advice. Does not recommend doses, protocols, or treatments.
- Studies cited
- 5
- Research grade
- C
- Experience
- 99
- Activity
- 85
Overall check-ins
Trackers & reports
Overview
About Melanotan II
Melanotan II (MT-II) is a synthetic analog of α-melanocyte-stimulating hormone (α-MSH) studied for skin tanning, erectile function, and appetite suppression. Not FDA-approved and associated with significant safety concerns including dangerous nausea, uncontrolled melanocytic changes (nevi/moles), hypertension, and priapism. The FDA has issued multiple warnings. Banned from 503A compounding. Use with extreme caution.
- Category
- Sexual Health
- Regulatory status
- ⚠️ Not Approved — Caution
- Also known as
- MT-II
- Self-reports
- 46
Community
What 46 users report
46 community reports
Overall experience
From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Favorable 97% · Mixed 3% · Unfavorable overall 0%
Most reported benefits
Benefits users selected when logging a favorable or mixed check-in.
Mood
142
Libido
142
Appetite
74
Most logged side effects
Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Fatigue
2
Nausea
2
Self-reported dose per injection
Median bucket: 0.4–0.6 mg · Most common: 0.2–0.4 mg
Reports span 0.01–2 mg
0.01–0.025 mg
1
0.05–0.1 mg
1
0.1–0.2 mg
7
0.2–0.4 mg
48
0.4–0.6 mg
23
0.6–1 mg
33
1–2 mg
29
Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.
Commonly stacked with
How repeat users are trending
Among repeat reporters, 94% said they felt similar to their last entry, 6% more positive, and 0% more negative.
Overall, repeat reporters leaned more positive than their previous entry.
Median gap between entries: 50 days · Based on 32 repeat reporters
Research
Cited research (3)
Source
PubMed
LC-HRMS characterization of the skin pigmentation and sexual enhancers melanotan II and bremelanotide sold on the black market of performance and image enhancing drugs
Mestria et al., 2021
PubMed
Melanotan II injection resulting in systemic toxicity and rhabdomyolysis
Nelson et al., 2012
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Frequently asked
What do PeptIQ users report about Melanotan II?
This page summarizes 46 anonymized self-reports from PeptIQ users who track Melanotan II, including commonly reported effects and co-tracked peptides. These are observational patterns, not clinical outcomes.
How do side effects relate to overall experience for Melanotan II?
PeptIQ separates overall check-in ratings (favorable, mixed, or unfavorable) from logged side effects like nausea or fatigue. Users often report benefits and side effects in the same check-in — a high experience score does not mean zero side effects were noted.
What research is cited for Melanotan II?
3 sources are linked on this page, including PubMed articles, clinical trial registries, and FDA labels where applicable. Citations describe published research — not recommendations.
Is Melanotan II safe to use?
This wiki does not assess safety or recommend use. Melanotan II is listed as ⚠️ Not Approved — Caution. Consult a licensed clinician for personal medical decisions.
What are the purported benefits and uses of Melanotan II?
Research, primarily in animal models, suggests Melanotan II may have a wide range of therapeutic potentials due to its ability to promote angiogenesis (formation of new blood vessels), stimulate collagen synthesis, and modulate inflammatory responses.
SourceWhat is the legal status of Melanotan II?
Melanotan II is not approved by the FDA for any human use. There is no legal basis for selling it as a drug, food, or dietary supplement in the United States. The FDA has classified Melanotan II as a Category 2 bulk drug substance, which explicitly prohibits licensed compounding pharmacies from using it in compounded medications.
SourceWhat are the known or theoretical side effects and risks of Melanotan II?
The safety and effectiveness of Melanotan II have not been thoroughly evaluated in humans through rigorous clinical trials. This lack of human data means that safe dosages, short-term side effects, and long-term health consequences are largely unknown.
SourceWhat is the current state of research on Melanotan II?
While there are over 200 published studies on Melanotan II, the vast majority are animal or in vitro (cell) studies. These preclinical studies consistently show positive results across various tissue types. However, there is a significant lack of comprehensive human clinical trial data.
Source