Sexual Health⚠️ Not Approved — CautionS

Melanotan II

MT-II

Melanotan II (MT-II) is a synthetic analog of α-melanocyte-stimulating hormone (α-MSH) studied for skin tanning, erectile function, and appetite suppression. Not FDA-approved and associated with significant safety concerns including dangerous nausea, uncontrolled melanocytic changes (nevi/moles), hypertension, and priapism. The FDA has issued multiple warnings. Banned from 503A compounding. Use with extreme caution.

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Observational report only — live community data. Not medical advice. Does not recommend doses, protocols, or treatments.
Studies cited
3
Research grade
S
Community score
179

Trend index

Trackers
3,922

Overview

About Melanotan II

Melanotan II (MT-II) is a synthetic analog of α-melanocyte-stimulating hormone (α-MSH) studied for skin tanning, erectile function, and appetite suppression. Not FDA-approved and associated with significant safety concerns including dangerous nausea, uncontrolled melanocytic changes (nevi/moles), hypertension, and priapism. The FDA has issued multiple warnings. Banned from 503A compounding. Use with extreme caution.

Category
Sexual Health
Regulatory status
⚠️ Not Approved — Caution
Also known as
MT-II
Self-reports
46

Community

What 46 users report

46 community reports

Positive 97% · Neutral 3% · Negative 0%

Most reported benefits

Mood
142
Libido
142
Appetite
74

Most reported side effects

Fatigue
2
Nausea
2

Dose distribution

Median: 400–600 mcg · Most common: 200–400 mcg

0–25
1
25–50
0
50–100
1
100–200
7
200–400
48
400–600
23
600–1000
33
1000–2000
29
2000+
0

How repeat users are trending

Among repeat reporters, 94% said they felt similar to their last entry, 6% more positive, and 0% more negative.

Overall, repeat reporters leaned more positive than their previous entry.

Median gap between entries: 50 days · Based on 32 repeat reporters

Research

Cited research (1)

Help

Frequently asked

What do PeptIQ users report about Melanotan II?

This page summarizes 46 anonymized self-reports from PeptIQ users who track Melanotan II, including commonly reported effects and co-tracked peptides. These are observational patterns, not clinical outcomes.

What research is cited for Melanotan II?

1 sources are linked on this page, including PubMed articles, clinical trial registries, and FDA labels where applicable. Citations describe published research — not recommendations.

Is Melanotan II safe to use?

This wiki does not assess safety or recommend use. Melanotan II is listed as ⚠️ Not Approved — Caution. Consult a licensed clinician for personal medical decisions.

What are the purported benefits and uses of Melanotan II?

Research, primarily in animal models, suggests Melanotan II may have a wide range of therapeutic potentials due to its ability to promote angiogenesis (formation of new blood vessels), stimulate collagen synthesis, and modulate inflammatory responses.

Source

What is the legal status of Melanotan II?

Melanotan II is not approved by the FDA for any human use. There is no legal basis for selling it as a drug, food, or dietary supplement in the United States. The FDA has classified Melanotan II as a Category 2 bulk drug substance, which explicitly prohibits licensed compounding pharmacies from using it in compounded medications.

Source

What are the known or theoretical side effects and risks of Melanotan II?

The safety and effectiveness of Melanotan II have not been thoroughly evaluated in humans through rigorous clinical trials. This lack of human data means that safe dosages, short-term side effects, and long-term health consequences are largely unknown.

Source

What is the current state of research on Melanotan II?

While there are over 200 published studies on Melanotan II, the vast majority are animal or in vitro (cell) studies. These preclinical studies consistently show positive results across various tissue types. However, there is a significant lack of comprehensive human clinical trial data.

Source