PubMed
Thymosin alpha 1: A comprehensive review of the literature
Romani et al., 2020
Tα1 / Zadaxin
Thymosin alpha-1 (Tα1, brand: Zadaxin) is a 28-amino acid peptide naturally produced by the thymus gland that plays a central role in modulating T-cell maturation and immune response. Approved in 40+ countries for hepatitis B, hepatitis C treatment adjuvancy, and as immune support in cancer patients. In the US, available through compounding pharmacies for immune support. Studied for COVID-19 severity reduction.
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Overview
Thymosin alpha-1 (Tα1, brand: Zadaxin) is a 28-amino acid peptide naturally produced by the thymus gland that plays a central role in modulating T-cell maturation and immune response. Approved in 40+ countries for hepatitis B, hepatitis C treatment adjuvancy, and as immune support in cancer patients. In the US, available through compounding pharmacies for immune support. Studied for COVID-19 severity reduction.
Community
Positive 100% · Neutral 0% · Negative 0%
Median: 400–600 mcg · Most common: 400–600 mcg
Research
PubMed
Romani et al., 2020
PubMed
Tuthill et al., 2017
PubMed
Garaci et al., 2014
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This page summarizes 6 anonymized self-reports from PeptIQ users who track Thymosin Alpha-1, including commonly reported effects and co-tracked peptides. These are observational patterns, not clinical outcomes.
3 sources are linked on this page, including PubMed articles, clinical trial registries, and FDA labels where applicable. Citations describe published research — not recommendations.
This wiki does not assess safety or recommend use. Thymosin Alpha-1 is listed as Compoundable (US) — Approved Internationally. Consult a licensed clinician for personal medical decisions.
Research, primarily in animal models, suggests Thymosin Alpha-1 may have a wide range of therapeutic potentials due to its ability to promote angiogenesis (formation of new blood vessels), stimulate collagen synthesis, and modulate inflammatory responses.
SourceThymosin Alpha-1 is not approved by the FDA for any human use. There is no legal basis for selling it as a drug, food, or dietary supplement in the United States. The FDA has classified Thymosin Alpha-1 as a Category 2 bulk drug substance, which explicitly prohibits licensed compounding pharmacies from using it in compounded medications.
SourceThe safety and effectiveness of Thymosin Alpha-1 have not been thoroughly evaluated in humans through rigorous clinical trials. This lack of human data means that safe dosages, short-term side effects, and long-term health consequences are largely unknown.
SourceWhile there are over 200 published studies on Thymosin Alpha-1, the vast majority are animal or in vitro (cell) studies. These preclinical studies consistently show positive results across various tissue types. However, there is a significant lack of comprehensive human clinical trial data.
Source