Healing & RecoveryResearch OnlyS

TB-500

Thymosin Beta-4 Fragment

TB-500 is the active synthetic fragment of thymosin beta-4 (Tβ4), a 43-amino acid protein naturally present in virtually all human cells and critical to actin regulation, cell migration, and tissue regeneration. Research shows TB-500 promotes angiogenesis, reduces inflammation, improves tissue flexibility, and accelerates recovery from musculoskeletal injuries. Not FDA-approved; banned from 503A compounding pharmacies.

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Observational report only — live community data. Not medical advice. Does not recommend doses, protocols, or treatments.
Studies cited
4
Research grade
S
Community score
161

Trend index

Trackers
2,958

Overview

About TB-500

TB-500 is the active synthetic fragment of thymosin beta-4 (Tβ4), a 43-amino acid protein naturally present in virtually all human cells and critical to actin regulation, cell migration, and tissue regeneration. Research shows TB-500 promotes angiogenesis, reduces inflammation, improves tissue flexibility, and accelerates recovery from musculoskeletal injuries. Not FDA-approved; banned from 503A compounding pharmacies.

Category
Healing & Recovery
Regulatory status
Research Only
Also known as
Thymosin Beta-4 Fragment
Self-reports
103

Community

What 103 users report

103 community reports

Positive 38% · Neutral 62% · Negative 0%

Most reported benefits

Recovery
219

Most reported side effects

Headache
70
Fatigue
65

Dose distribution

Median: 2000+ mcg · Most common: 2000+ mcg

0–25
14
25–50
1
50–100
0
100–200
1
200–400
29
400–600
25
600–1000
2
1000–2000
5
2000+
142

How repeat users are trending

Among repeat reporters, 57% said they felt similar to their last entry, 23% more positive, and 20% more negative.

Overall, repeat reporters leaned more positive than their previous entry.

Median gap between entries: 63 days · Based on 40 repeat reporters

Research

Cited research (2)

Help

Frequently asked

What do PeptIQ users report about TB-500?

This page summarizes 103 anonymized self-reports from PeptIQ users who track TB-500, including commonly reported effects and co-tracked peptides. These are observational patterns, not clinical outcomes.

What research is cited for TB-500?

2 sources are linked on this page, including PubMed articles, clinical trial registries, and FDA labels where applicable. Citations describe published research — not recommendations.

Is TB-500 safe to use?

This wiki does not assess safety or recommend use. TB-500 is listed as Research Only. Consult a licensed clinician for personal medical decisions.

What are the purported benefits and uses of TB-500?

Research, primarily in animal models, suggests TB-500 may have a wide range of therapeutic potentials due to its ability to promote angiogenesis (formation of new blood vessels), stimulate collagen synthesis, and modulate inflammatory responses.

Source

What is the legal status of TB-500?

TB-500 is not approved by the FDA for any human use. There is no legal basis for selling it as a drug, food, or dietary supplement in the United States. The FDA has classified TB-500 as a Category 2 bulk drug substance, which explicitly prohibits licensed compounding pharmacies from using it in compounded medications.

Source

What are the known or theoretical side effects and risks of TB-500?

The safety and effectiveness of TB-500 have not been thoroughly evaluated in humans through rigorous clinical trials. This lack of human data means that safe dosages, short-term side effects, and long-term health consequences are largely unknown.

Source

What is the current state of research on TB-500?

While there are over 200 published studies on TB-500, the vast majority are animal or in vitro (cell) studies. These preclinical studies consistently show positive results across various tissue types. However, there is a significant lack of comprehensive human clinical trial data.

Source