PubMed
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging (FOXO4-DRI)
Baar et al., 2017
Longevity & Anti-AgingResearch OnlyC
FOXO4-DRI
Senolytic Peptide FOXO4
FOXO4-DRI is a D-amino acid retro-inverso (DRI) peptide designed to disrupt the interaction between the FOXO4 transcription factor and p53 protein that keeps senescent cells (zombie cells) alive. Published mouse studies (Nature 2017) showed that FOXO4-DRI selectively induced apoptosis of senescent cells, improving fitness, coat density, and kidney function. No human clinical trials have been published. Research only; handle with caution.
Observational report only — live community data. Not medical advice. Does not recommend doses, protocols, or treatments.
- Studies cited
- 5
- Research grade
- C
- Experience
- 99
- Activity
- 78
Overall check-ins
Trackers & reports
Overview
About FOXO4-DRI
FOXO4-DRI is a D-amino acid retro-inverso (DRI) peptide designed to disrupt the interaction between the FOXO4 transcription factor and p53 protein that keeps senescent cells (zombie cells) alive. Published mouse studies (Nature 2017) showed that FOXO4-DRI selectively induced apoptosis of senescent cells, improving fitness, coat density, and kidney function. No human clinical trials have been published. Research only; handle with caution.
- Category
- Longevity & Anti-Aging
- Regulatory status
- Research Only
- Also known as
- Senolytic Peptide FOXO4
- Self-reports
- 28
Community
What 28 users report
28 community reports
Overall experience
From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Favorable 97% · Mixed 3% · Unfavorable overall 0%
Most reported benefits
Benefits users selected when logging a favorable or mixed check-in.
Recovery
178
Energy
178
Self-reported dose per injection
Median bucket: 2+ mg · Most common: 2+ mg
Reports span 1 to ≥ 2 mg (open-ended top bucket)
1–2 mg
58
2+ mg
120
Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.
Commonly stacked with
How repeat users are trending
Among repeat reporters, 88% said they felt similar to their last entry, 12% more positive, and 0% more negative.
Overall, repeat reporters leaned more positive than their previous entry.
Median gap between entries: 194 days · Based on 26 repeat reporters
Research
Cited research (3)
Source
PubMed
Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression
Born et al., 2023
PubMed
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
Baar et al., 2017
Tools
Explore more
Explore
More ways to learn about FOXO4-DRI from observational PeptIQ data.
Related peptides
Help
Frequently asked
What do PeptIQ users report about FOXO4-DRI?
This page summarizes 28 anonymized self-reports from PeptIQ users who track FOXO4-DRI, including commonly reported effects and co-tracked peptides. These are observational patterns, not clinical outcomes.
How do side effects relate to overall experience for FOXO4-DRI?
PeptIQ separates overall check-in ratings (favorable, mixed, or unfavorable) from logged side effects like nausea or fatigue. Users often report benefits and side effects in the same check-in — a high experience score does not mean zero side effects were noted.
What research is cited for FOXO4-DRI?
3 sources are linked on this page, including PubMed articles, clinical trial registries, and FDA labels where applicable. Citations describe published research — not recommendations.
Is FOXO4-DRI safe to use?
This wiki does not assess safety or recommend use. FOXO4-DRI is listed as Research Only. Consult a licensed clinician for personal medical decisions.
What are the purported benefits and uses of FOXO4-DRI?
This wiki summarizes observational community reports and linked citations for FOXO4-DRI. It does not assert therapeutic benefits. See the cited research list on this page and the educational profile for FOXO4-DRI for study-level context — not medical advice.
What is the legal status of FOXO4-DRI?
FOXO4-DRI is listed in PeptIQ as Research Only. Regulatory status varies by jurisdiction and can change. This wiki does not provide legal advice; check current FDA and local rules and talk with a licensed clinician or counsel for personal decisions.
What are the known or theoretical side effects and risks of FOXO4-DRI?
Safety data quality for FOXO4-DRI varies widely by compound and study design. PeptIQ does not establish a risk profile here. Review primary literature, product labeling where applicable, and clinician guidance. Community self-reports are not a substitute for clinical evidence.
What is the current state of research on FOXO4-DRI?
This page links 3 indexed sources for FOXO4-DRI. Evidence maturity differs by application — some peptides have large human programs, others are mostly preclinical. Treat citation counts as literature volume, not proof of efficacy.