PubMed
Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence
Anisimov et al., 2003
Longevity & Anti-AgingResearch OnlyA
Epithalon
Epitalon / Epithalamin
Epithalon (epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural peptide epithalamin extracted from the pineal gland. Pioneered by Russian researcher Vladimir Khavinson, studies suggest it may stimulate telomerase activity and extend telomere length, regulate melatonin production, and normalize neuroendocrine system function. Mostly animal and limited human aging studies; not FDA-approved. It is typically reconstituted with bacteriostatic water and injected on its own during short 10–20 day cycles; there is no published same-syringe compatibility data for combining Epithalon with other peptides, so co-administration is best done as separate injections.
Observational report only — live community data. Not medical advice. Does not recommend doses, protocols, or treatments.
- Studies cited
- 15
- Research grade
- A
- Experience
- 56
- Activity
- 40
Overall check-ins
Trackers & reports
Overview
About Epithalon
Epithalon (epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural peptide epithalamin extracted from the pineal gland. Pioneered by Russian researcher Vladimir Khavinson, studies suggest it may stimulate telomerase activity and extend telomere length, regulate melatonin production, and normalize neuroendocrine system function. Mostly animal and limited human aging studies; not FDA-approved. It is typically reconstituted with bacteriostatic water and injected on its own during short 10–20 day cycles; there is no published same-syringe compatibility data for combining Epithalon with other peptides, so co-administration is best done as separate injections.
- Category
- Longevity & Anti-Aging
- Regulatory status
- Research Only
- Also known as
- Epitalon / Epithalamin
- Self-reports
- 37
Community
What 37 users report
37 community reports
Overall experience
From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Favorable 3% · Mixed 97% · Unfavorable overall 0%
Most reported benefits
Benefits users selected when logging a favorable or mixed check-in.
Energy
160
Sleep
160
Most logged side effects
Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Injection site irritation
155
Self-reported dose per injection
Median bucket: 2+ mg · Most common: 2+ mg
Reports span 0 to ≥ 2 mg (open-ended top bucket)
0–0.025 mg
4
0.2–0.4 mg
5
0.4–0.6 mg
14
1–2 mg
4
2+ mg
133
Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.
Commonly stacked with
How repeat users are trending
Among repeat reporters, 86% said they felt similar to their last entry, 14% more positive, and 0% more negative.
Overall, repeat reporters leaned more positive than their previous entry.
Median gap between entries: 32 days · Based on 35 repeat reporters
Research
Cited research (13)
Source
PubMed
Epitalon peptide induces telomerase activity in human somatic cells
Khavinson et al., 2003
PubMed
Peptide bioregulation of aging: results of a 15-year study
Khavinson, 2002
ClinicalTrials.gov
Epitalon / epithalon studies on ClinicalTrials.gov
ClinicalTrials.gov, 2024
PubMed
Peptide promotes overcoming of the division limit in human somatic cell
Khavinson et al., 2004
PubMed
Reparative effect of epithalon on pineal gland ultrastructure in gamma-irradiated rats
Khavinson et al., 2001
PubMed
Effect of pineal peptides on neuroendocrine system after pinealectomy
Khavinson et al., 2001
PubMed
Modulating effects of epithalamin and epithalon on the functional morphology of the spleen in old pinealectomized rats
Khavinson et al., 2001
PubMed
Aging of the pineal gland
Khavinson et al., 2002
PubMed
Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa
Khavinson et al., 2002
Review Article
Peptides and Ageing
Khavinson, 2002
PubMed
AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism
Khavinson et al., 2020
Review Article
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
Rahman et al., 2026
Tools
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Frequently asked
What do PeptIQ users report about Epithalon?
This page summarizes 37 anonymized self-reports from PeptIQ users who track Epithalon, including commonly reported effects and co-tracked peptides. These are observational patterns, not clinical outcomes.
How do side effects relate to overall experience for Epithalon?
PeptIQ separates overall check-in ratings (favorable, mixed, or unfavorable) from logged side effects like nausea or fatigue. Users often report benefits and side effects in the same check-in — a high experience score does not mean zero side effects were noted.
What research is cited for Epithalon?
13 sources are linked on this page, including PubMed articles, clinical trial registries, and FDA labels where applicable. Citations describe published research — not recommendations.
Is Epithalon safe to use?
This wiki does not assess safety or recommend use. Epithalon is listed as Research Only. Consult a licensed clinician for personal medical decisions.
What are the purported benefits and uses of Epithalon?
Research, primarily in animal models, suggests Epithalon may have a wide range of therapeutic potentials due to its ability to promote angiogenesis (formation of new blood vessels), stimulate collagen synthesis, and modulate inflammatory responses.
SourceWhat is the legal status of Epithalon?
Epithalon is not approved by the FDA for any human use. There is no legal basis for selling it as a drug, food, or dietary supplement in the United States. The FDA has classified Epithalon as a Category 2 bulk drug substance, which explicitly prohibits licensed compounding pharmacies from using it in compounded medications.
SourceWhat are the known or theoretical side effects and risks of Epithalon?
The safety and effectiveness of Epithalon have not been thoroughly evaluated in humans through rigorous clinical trials. This lack of human data means that safe dosages, short-term side effects, and long-term health consequences are largely unknown.
SourceWhat is the current state of research on Epithalon?
While there are over 200 published studies on Epithalon, the vast majority are animal or in vitro (cell) studies. These preclinical studies consistently show positive results across various tissue types. However, there is a significant lack of comprehensive human clinical trial data.
Source