Longevity & Anti-AgingResearch OnlyS

Epithalon

Epitalon / Epithalamin

Epithalon (epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural peptide epithalamin extracted from the pineal gland. Pioneered by Russian researcher Vladimir Khavinson, studies suggest it may stimulate telomerase activity and extend telomere length, regulate melatonin production, and normalize neuroendocrine system function. Mostly animal and limited human aging studies; not FDA-approved.

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Observational report only — live community data. Not medical advice. Does not recommend doses, protocols, or treatments.
Studies cited
5
Research grade
S
Community score
47

Trend index

Trackers
148

Overview

About Epithalon

Epithalon (epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural peptide epithalamin extracted from the pineal gland. Pioneered by Russian researcher Vladimir Khavinson, studies suggest it may stimulate telomerase activity and extend telomere length, regulate melatonin production, and normalize neuroendocrine system function. Mostly animal and limited human aging studies; not FDA-approved.

Category
Longevity & Anti-Aging
Regulatory status
Research Only
Also known as
Epitalon / Epithalamin
Self-reports
37

Community

What 37 users report

37 community reports

Positive 3% · Neutral 97% · Negative 0%

Most reported benefits

Energy
160
Sleep
160

Most reported side effects

Injection site irritation
155

Dose distribution

Median: 2000+ mcg · Most common: 2000+ mcg

0–25
4
25–50
0
50–100
0
100–200
0
200–400
5
400–600
14
600–1000
0
1000–2000
4
2000+
133

How repeat users are trending

Among repeat reporters, 86% said they felt similar to their last entry, 14% more positive, and 0% more negative.

Overall, repeat reporters leaned more positive than their previous entry.

Median gap between entries: 32 days · Based on 35 repeat reporters

Research

Cited research (3)

PubMed

Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence

Anisimov et al., 2003

Source
Wiki study page →

Help

Frequently asked

What do PeptIQ users report about Epithalon?

This page summarizes 37 anonymized self-reports from PeptIQ users who track Epithalon, including commonly reported effects and co-tracked peptides. These are observational patterns, not clinical outcomes.

What research is cited for Epithalon?

3 sources are linked on this page, including PubMed articles, clinical trial registries, and FDA labels where applicable. Citations describe published research — not recommendations.

Is Epithalon safe to use?

This wiki does not assess safety or recommend use. Epithalon is listed as Research Only. Consult a licensed clinician for personal medical decisions.

What are the purported benefits and uses of Epithalon?

Research, primarily in animal models, suggests Epithalon may have a wide range of therapeutic potentials due to its ability to promote angiogenesis (formation of new blood vessels), stimulate collagen synthesis, and modulate inflammatory responses.

Source

What is the legal status of Epithalon?

Epithalon is not approved by the FDA for any human use. There is no legal basis for selling it as a drug, food, or dietary supplement in the United States. The FDA has classified Epithalon as a Category 2 bulk drug substance, which explicitly prohibits licensed compounding pharmacies from using it in compounded medications.

Source

What are the known or theoretical side effects and risks of Epithalon?

The safety and effectiveness of Epithalon have not been thoroughly evaluated in humans through rigorous clinical trials. This lack of human data means that safe dosages, short-term side effects, and long-term health consequences are largely unknown.

Source

What is the current state of research on Epithalon?

While there are over 200 published studies on Epithalon, the vast majority are animal or in vitro (cell) studies. These preclinical studies consistently show positive results across various tissue types. However, there is a significant lack of comprehensive human clinical trial data.

Source