GH SecretagoguesFDA ApprovedS

Sermorelin

GHRH 1-29

Sermorelin acetate (GHRH 1-29) is a synthetic analog of the first 29 amino acids of endogenous growth hormone-releasing hormone. FDA-approved for diagnosing and treating GH deficiency, it stimulates the pituitary gland to produce and secrete growth hormone naturally — a preferred alternative to exogenous HGH therapy for physiological GH optimization. Available by prescription through compounding pharmacies and telehealth providers.

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Observational report only — live community data. Not medical advice. Does not recommend doses, protocols, or treatments.
Studies cited
4
Research grade
S
Community score
125

Trend index

Trackers
2,484

Overview

About Sermorelin

Sermorelin acetate (GHRH 1-29) is a synthetic analog of the first 29 amino acids of endogenous growth hormone-releasing hormone. FDA-approved for diagnosing and treating GH deficiency, it stimulates the pituitary gland to produce and secrete growth hormone naturally — a preferred alternative to exogenous HGH therapy for physiological GH optimization. Available by prescription through compounding pharmacies and telehealth providers.

Category
GH Secretagogues
Regulatory status
FDA Approved
Also known as
GHRH 1-29
Self-reports
36

Community

What 36 users report

36 community reports

Positive 90% · Neutral 10% · Negative 0%

Most reported benefits

Sleep
145
Energy
145

Most reported side effects

Injection site irritation
7
Headache
7

Dose distribution

Median: 200–400 mcg · Most common: 200–400 mcg

0–25
0
25–50
0
50–100
0
100–200
0
200–400
99
400–600
40
600–1000
0
1000–2000
3
2000+
3

How repeat users are trending

Among repeat reporters, 81% said they felt similar to their last entry, 8% more positive, and 12% more negative.

Overall, repeat reporters leaned more negative than their previous entry.

Median gap between entries: 105 days · Based on 26 repeat reporters

Research

Cited research (2)

Help

Frequently asked

What do PeptIQ users report about Sermorelin?

This page summarizes 36 anonymized self-reports from PeptIQ users who track Sermorelin, including commonly reported effects and co-tracked peptides. These are observational patterns, not clinical outcomes.

What research is cited for Sermorelin?

2 sources are linked on this page, including PubMed articles, clinical trial registries, and FDA labels where applicable. Citations describe published research — not recommendations.

Is Sermorelin safe to use?

This wiki does not assess safety or recommend use. Sermorelin is listed as FDA Approved. Consult a licensed clinician for personal medical decisions.

What are the purported benefits and uses of Sermorelin?

Research, primarily in animal models, suggests Sermorelin may have a wide range of therapeutic potentials due to its ability to promote angiogenesis (formation of new blood vessels), stimulate collagen synthesis, and modulate inflammatory responses.

Source

What is the legal status of Sermorelin?

Sermorelin is not approved by the FDA for any human use. There is no legal basis for selling it as a drug, food, or dietary supplement in the United States. The FDA has classified Sermorelin as a Category 2 bulk drug substance, which explicitly prohibits licensed compounding pharmacies from using it in compounded medications.

Source

What are the known or theoretical side effects and risks of Sermorelin?

The safety and effectiveness of Sermorelin have not been thoroughly evaluated in humans through rigorous clinical trials. This lack of human data means that safe dosages, short-term side effects, and long-term health consequences are largely unknown.

Source

What is the current state of research on Sermorelin?

While there are over 200 published studies on Sermorelin, the vast majority are animal or in vitro (cell) studies. These preclinical studies consistently show positive results across various tissue types. However, there is a significant lack of comprehensive human clinical trial data.

Source