PubMed
NAD+ metabolism and its roles in cellular processes during ageing
Covarrubias et al., 2021
Longevity & Anti-AgingSupplement / Clinical UseS
NAD+
Nicotinamide Adenine Dinucleotide
Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme present in all living cells, central to energy metabolism (cellular respiration), DNA repair, and sirtuins-mediated gene expression regulation. NAD+ levels decline significantly with aging. IV and subcutaneous NAD+ infusion clinics have grown substantially for anti-aging, metabolic health, cognitive support, and addiction recovery. Oral precursors (NMN, NR) are widely available as supplements.
Observational report only — live community data. Not medical advice. Does not recommend doses, protocols, or treatments.
- Studies cited
- 10
- Research grade
- S
- Experience
- 56
- Activity
- 79
Overall check-ins
Trackers & reports
Overview
About NAD+
Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme present in all living cells, central to energy metabolism (cellular respiration), DNA repair, and sirtuins-mediated gene expression regulation. NAD+ levels decline significantly with aging. IV and subcutaneous NAD+ infusion clinics have grown substantially for anti-aging, metabolic health, cognitive support, and addiction recovery. Oral precursors (NMN, NR) are widely available as supplements.
- Category
- Longevity & Anti-Aging
- Regulatory status
- Supplement / Clinical Use
- Also known as
- Nicotinamide Adenine Dinucleotide
- Self-reports
- 96
Community
What 96 users report
96 community reports
Overall experience
From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Favorable 2% · Mixed 98% · Unfavorable overall 0%
Most reported benefits
Benefits users selected when logging a favorable or mixed check-in.
Energy
197
Appetite
197
Most logged side effects
Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Headache
66
Nausea
64
Injection site irritation
64
Self-reported dose per injection
Median bucket: 5+ mg · Most common: 5+ mg
Reports span 0.1 to ≥ 5 mg (open-ended top bucket)
0.1–0.2 mg
2
0.2–0.4 mg
17
0.4–0.6 mg
8
0.6–1 mg
1
1–2 mg
2
3–5 mg
2
5+ mg
165
Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.
Commonly stacked with
How repeat users are trending
Among repeat reporters, 95% said they felt similar to their last entry, 5% more positive, and 0% more negative.
Overall, repeat reporters leaned more positive than their previous entry.
Median gap between entries: 51 days · Based on 42 repeat reporters
Research
Cited research (8)
Source
PubMed
Safety and efficacy of NAD+ supplementation: a systematic review
Reiten et al., 2021
PubMed
NAD+ intermediates: The biology and therapeutic potential
Yoshino et al., 2018
ClinicalTrials.gov
NAD+ studies on ClinicalTrials.gov
ClinicalTrials.gov, 2024
PubMed
Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns
Bhasin et al., 2023
PubMed
NAD⁺ in aging, metabolism, and neurodegeneration
Verdin, 2015
PubMed
NAD+ and sirtuins in aging and disease
Imai et al., 2014
PubMed
The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update
Song et al., 2023
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Frequently asked
What do PeptIQ users report about NAD+?
This page summarizes 96 anonymized self-reports from PeptIQ users who track NAD+, including commonly reported effects and co-tracked peptides. These are observational patterns, not clinical outcomes.
How do side effects relate to overall experience for NAD+?
PeptIQ separates overall check-in ratings (favorable, mixed, or unfavorable) from logged side effects like nausea or fatigue. Users often report benefits and side effects in the same check-in — a high experience score does not mean zero side effects were noted.
What research is cited for NAD+?
8 sources are linked on this page, including PubMed articles, clinical trial registries, and FDA labels where applicable. Citations describe published research — not recommendations.
Is NAD+ safe to use?
This wiki does not assess safety or recommend use. NAD+ is listed as Supplement / Clinical Use. Consult a licensed clinician for personal medical decisions.
What are the purported benefits and uses of NAD+?
This wiki summarizes observational community reports and linked citations for NAD+. It does not assert therapeutic benefits. See the cited research list on this page and the educational profile for NAD+ for study-level context — not medical advice.
What is the legal status of NAD+?
NAD+ is listed in PeptIQ as Supplement / Clinical Use. Regulatory status varies by jurisdiction and can change. This wiki does not provide legal advice; check current FDA and local rules and talk with a licensed clinician or counsel for personal decisions.
What are the known or theoretical side effects and risks of NAD+?
Safety data quality for NAD+ varies widely by compound and study design. PeptIQ does not establish a risk profile here. Review primary literature, product labeling where applicable, and clinician guidance. Community self-reports are not a substitute for clinical evidence.
What is the current state of research on NAD+?
This page links 8 indexed sources for NAD+. Evidence maturity differs by application — some peptides have large human programs, others are mostly preclinical. Treat citation counts as literature volume, not proof of efficacy.