Peptides researched for
Gut inflammation / leaky gut
A calmer gut
3 peptides · 4 studies
What people research this for
Bloating, discomfort, and worries about a leaky gut bring a lot of people here. The hope is a calmer, more settled digestive system. Research on peptides for the gut lining is mostly in cells and animals.
Researched for
- Gut lining health
- Digestive inflammation
- Leaky gut
What the studies say so far
KPV has been studied in gut cells and in mice for its effect on inflammation. Reviews discuss VIP as a molecule that helps regulate immune activity in the gut. Larazotide has been studied in celiac disease for how it affects the seals between gut cells, which control how leaky the gut lining is. Evidence in people is sparse for most of these.
Peptides studied
Each peptide below has been studied in this area. The label shows how far that research has gone.
KPV
Early lab and animal researchAnimal study · 1 study
Study note. Intestinal epithelial anti-inflammatory effects in cell and murine models.
- Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease (opens in a new tab)
Kannengiesser K, Maaser C, Heidemann J · Inflamm Bowel Dis · 2008 · PubMed
- Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease (opens in a new tab)
VIP
Small early studies in peopleResearch review · 2 studies
Study note. VIP discussed as an immunomodulatory neuropeptide in barrier and inflammatory pathways.
- The significance of vasoactive intestinal peptide in immunomodulation. (opens in a new tab)
Delgado M, Pozo D, Ganea D · Pharmacological reviews · 2004 · PubMed
- Vasoactive Intestinal Peptide studies on ClinicalTrials.gov (opens in a new tab)
Clinical trial registry · 2024 · ClinicalTrials.gov
- The significance of vasoactive intestinal peptide in immunomodulation. (opens in a new tab)
Larazotide
Small early studies in peopleResearch review · 1 study
Study note. Larazotide acetate reviews focus on tight-junction regulation relevant to intestinal permeability research.
- The potential utility of tight junction regulation in celiac disease: focus on larazotide acetate. (opens in a new tab)
Khaleghi S, Ju JM, Lamba A · Therapeutic advances in gastroenterology · 2016 · PubMed
- The potential utility of tight junction regulation in celiac disease: focus on larazotide acetate. (opens in a new tab)
Look this up in the PeptIQ app
The app has the same research and sources, next to the tools you use to track your own protocol.
