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MK-677 vs Selank

Side-by-side observational reports from PeptIQ users. This compares self-reported patterns — not clinical head-to-head trials.

Last reviewed . By the PeptIQ team.

Observational reporting only — not medical advice. Does not recommend doses, protocols, or treatments.
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MK-677

24 community reports

Overall experience

From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.

Favorable 98% · Mixed 2% · Unfavorable overall 0%

Most reported benefits

Benefits users selected when logging a favorable or mixed check-in.

Sleep
135

Most logged side effects

Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.

Water retention
2
Fatigue
1

Self-reported dose per injection

Median bucket: 2+ mg · Most common: 2+ mg

Reports span 2 to ≥ 2 mg (open-ended top bucket)

2+ mg
135

Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.

How repeat users are trending

Among repeat reporters, 91% said they felt similar to their last entry, 9% more positive, and 0% more negative.

Overall, repeat reporters leaned more positive than their previous entry.

Median gap between entries: 156 days · Based on 22 repeat reporters

Selank

57 community reports

Overall experience

From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.

Favorable 3% · Mixed 97% · Unfavorable overall 0%

Most reported benefits

Benefits users selected when logging a favorable or mixed check-in.

Mood
184
Recovery
184

Most logged side effects

Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.

Injection site irritation
94
Fatigue
85

Self-reported dose per injection

Median bucket: 0.2–0.4 mg · Most common: 0.2–0.4 mg

Reports span 0.1 to ≥ 5 mg (open-ended top bucket)

0.1–0.2 mg
3
0.2–0.4 mg
96
0.4–0.6 mg
76
0.6–1 mg
5
1–2 mg
2
5+ mg
2

Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.

How repeat users are trending

Among repeat reporters, 86% said they felt similar to their last entry, 14% more positive, and 0% more negative.

Overall, repeat reporters leaned more positive than their previous entry.

Median gap between entries: 54 days · Based on 35 repeat reporters

Sources (11)

Published sources linked on the MK-677 and Selank wiki pages.

  1. PubMed

    MK-677, an orally active growth hormone secretagogue: effects on body composition

    Murphy MG, Plunkett LM, Gertz BJ, et al. J Clin Endocrinol Metab. 1998

    Source
    Wiki study page →

  2. PubMed

    Two-year treatment with ibutamoren increases bone mineral density, body composition, and quality of life

    Nass R, Pezzoli SS, Oliveri MC, et al. J Clin Endocrinol Metab. 2008

    Source
    Wiki study page →

  3. ClinicalTrials.gov

    Ibutamoren (MK-677) studies on ClinicalTrials.gov

    ClinicalTrials.gov. Clinical trial registry. 2024

    Source
    Wiki study page →

  4. PubMed

    MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism

    Murphy MG, Plunkett LM, Gertz BJ, et al. The Journal of clinical endocrinology and metabolism. 1998

    Source
    Wiki study page →

  5. PubMed

    Characterization of growth hormone secretagogue small molecule ibutamoren (MK-0677) and its possible metabolites in thoroughbred horses for doping control

    Philip M, Karakka Kal AK, Subhahar MB, et al. Rapid communications in mass spectrometry : RCM. 2022

    Source
    Wiki study page →

  6. PubMed

    Selank and short peptides regulate expression of inflammatory genes

    Ershov FI, Uchakin PN, Ershova OV. Bull Exp Biol Med. 2017

    Source
    Wiki study page →

  7. PubMed

    Selank, a tuftsin analogue, demonstrates anxiolytic activity

    Seredenin SB, Kozlovskaya MM. Bull Exp Biol Med. 2008

    Source
    Wiki study page →

  10. PubMed

    Functional Connectomic Approach to Studying Selank and Semax Effects

    Panikratova YR, Lebedeva IS, Sokolov OY, et al. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections. 2020

    Source
    Wiki study page →

  11. PubMed

    Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats

    Konstantinopolsky MA, Chernyakova IV, Kolik LG. Bulletin of experimental biology and medicine. 2022

    Source
    Wiki study page →

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