PubMed
Des(1-3)IGF-I: a truncated form of insulin-like growth factor-I
Ballard FJ, Wallace JC, Francis GL, et al. Int J Biochem Cell Biol. 1996
Compare
IGF-1 DES vs NAD+
Side-by-side observational reports from PeptIQ users. This compares self-reported patterns — not clinical head-to-head trials.
Last reviewed . By the PeptIQ team.
Observational reporting only — not medical advice. Does not recommend doses, protocols, or treatments.
IGF-1 DES
2337 community reports
Overall experience
From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Favorable 51% · Mixed 32% · Unfavorable overall 17%
Most reported benefits
Benefits users selected when logging a favorable or mixed check-in.
Skin appearance
48
Appetite control
39
Energy
127
Mood
93
Focus
112
Most logged side effects
Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Headache
144
GI discomfort
118
Dizziness
92
Fatigue
89
Nausea
111
Self-reported dose per injection
Median bucket: 0.4–0.6 mg · Most common: 0.2–0.4 mg
Reports span 0.05–2 mg
0.05–0.1 mg
7
0.1–0.2 mg
15
0.2–0.4 mg
18
0.4–0.6 mg
14
0.6–1 mg
8
1–2 mg
2
Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.
Commonly stacked with
Common discussion topics
timing21stacking19side effects17igf-1 des20
How repeat users are trending
Among repeat reporters, 61% said they felt similar to their last entry, 43% more positive, and 21% more negative.
Overall, repeat reporters leaned more positive than their previous entry.
Median gap between entries: 23 days · Based on 514 repeat reporters
NAD+
96 community reports
Overall experience
From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Favorable 2% · Mixed 98% · Unfavorable overall 0%
Most reported benefits
Benefits users selected when logging a favorable or mixed check-in.
Energy
197
Appetite
197
Most logged side effects
Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Headache
66
Nausea
64
Injection site irritation
64
Self-reported dose per injection
Median bucket: 5+ mg · Most common: 5+ mg
Reports span 0.1 to ≥ 5 mg (open-ended top bucket)
0.1–0.2 mg
2
0.2–0.4 mg
17
0.4–0.6 mg
8
0.6–1 mg
1
1–2 mg
2
3–5 mg
2
5+ mg
165
Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.
Commonly stacked with
How repeat users are trending
Among repeat reporters, 95% said they felt similar to their last entry, 5% more positive, and 0% more negative.
Overall, repeat reporters leaned more positive than their previous entry.
Median gap between entries: 51 days · Based on 42 repeat reporters
Sources (14)
Published sources linked on the IGF-1 DES and NAD+ wiki pages.
- Wiki study page →Source
- Wiki study page →Source
PubMed
Enhanced potency of truncated insulin-like growth factor-I (des(1-3)IGF-I) relative to IGF-I in lit/lit mice
Gillespie C, Read LC, Bagley CJ, et al. J Endocrinol. 1990
- Wiki study page →Source
PubMed
In vivo actions of IGF analogues with poor affinities for IGFBPs: metabolic and growth effects in pigs of different ages and GH responsiveness
Walton PE, Dunshea FR, Ballard FJ. Prog Growth Factor Res. 1995
- Wiki study page →Source
PubMed
IGF-I variants which bind poorly to IGF-binding proteins show more potent and prolonged hypoglycaemic action than native IGF-I in pigs and marmoset monkeys
Tomas FM, Walton PE, Dunshea FR, et al. J Endocrinol. 1997
- Wiki study page →Source
PubMed
Insulin-like growth factor-I and its N-terminal modified analogues induce marked gut growth in dexamethasone-treated rats
Read LC, Tomas FM, Howarth GS, et al. J Endocrinol. 1992
- Wiki study page →Source
ClinicalTrials.gov
des(1-3)IGF-1 / IGF-1 DES studies on ClinicalTrials.gov
ClinicalTrials.gov. Clinical trial registry. 2024
- Wiki study page →Source
PubMed
NAD+ metabolism and its roles in cellular processes during ageing
Covarrubias AJ, Perrone R, Grozio A, et al. Nat Rev Mol Cell Biol. 2021
- Wiki study page →Source
PubMed
Safety and efficacy of NAD+ supplementation: a systematic review
Reiten OK, Wilvang MA, Mitchell SJ, et al. J Clin Invest. 2021
- Wiki study page →Source
PubMed
NAD+ intermediates: The biology and therapeutic potential
Yoshino J, Baur JA, Imai SI. Cell Metab. 2018
- Wiki study page →Source
ClinicalTrials.gov
NAD+ studies on ClinicalTrials.gov
ClinicalTrials.gov. Clinical trial registry. 2024
- Wiki study page →Source
PubMed
Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns
Bhasin S, Seals D, Migaud M, et al. Endocrine reviews. 2023
- Wiki study page →Source
PubMed
NAD⁺ in aging, metabolism, and neurodegeneration
Verdin E. Science (New York, N.Y.). 2015
- Wiki study page →Source
PubMed
NAD+ and sirtuins in aging and disease
Imai S, Guarente L. Trends in cell biology. 2014
- Wiki study page →Source
PubMed
The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update
Song Q, Zhou X, Xu K, et al. Advances in nutrition (Bethesda, Md.). 2023