Peptides researched for
Male hypogonadism / low testosterone
Low testosterone
3 peptides · 5 studies
What people research this for
Men with low testosterone often want to feel like themselves again, and many want to keep their fertility too. Researchers have studied a pill called enclomiphene and a few peptides that prompt the body to release growth hormone.
Researched for
- Low testosterone
- Protecting fertility
- Muscle and body fat
What the studies say so far
In a mid-stage randomized trial of men with a type of low testosterone, enclomiphene raised testosterone and kept sperm counts healthier than testosterone gel did. Ipamorelin and CJC-1295 belong to a group of peptides that prompt the body to release growth hormone. Small studies and reviews in men with low testosterone report higher levels of a growth marker called IGF-1 and discuss muscle and fat changes. The growth hormone peptides are not testosterone replacements and are not approved for low testosterone.
Peptides studied
Each peptide below has been studied in this area. The label shows how far that research has gone.
Enclomiphene
Tested in clinical trialsRandomized trial in people · 1 study
Study note. Phase 2 RCT: enclomiphene raised testosterone while mitigating oligospermia risk vs topical testosterone in secondary hypogonadism.
- Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone. (opens in a new tab)
Wiehle RD, Fontenot GK, Wike J · Fertility and sterility · 2014 · PubMed
- Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone. (opens in a new tab)
Ipamorelin
Small early studies in peopleObservational study in people · 2 studies
Study note. GH secretagogue literature in hypogonadal men reports IGF-1 increases and discusses body-composition management, not testosterone replacement.
- Growth Hormone Secretagogue Treatment in Hypogonadal Men Raises Serum Insulin-Like Growth Factor-1 Levels. (opens in a new tab)
Sigalos JT, Pastuszak AW, Allison A · American journal of men's health · 2017 · PubMed
- Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. (opens in a new tab)
Sinha DK, Balasubramanian A, Tatem AJ · Translational andrology and urology · 2020 · PubMed
- Growth Hormone Secretagogue Treatment in Hypogonadal Men Raises Serum Insulin-Like Growth Factor-1 Levels. (opens in a new tab)
CJC-1295 DAC
Small early studies in peopleResearch review · 2 studies
Study note. CJC-1295/GHS reviews place GHRH analogs in hypogonadal body-composition discussions; dedicated hypogonadism approvals are limited.
- Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. (opens in a new tab)
Sinha DK, Balasubramanian A, Tatem AJ · Translational andrology and urology · 2020 · PubMed
- Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults (opens in a new tab)
Teichman SL, Neale A, Lawrence B · J Clin Endocrinol Metab · 2006 · PubMed
- Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. (opens in a new tab)
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