SLU-PP-332: The ERRα Agonist That Gives You the Benefits of Exercise in a Vial
SLU-PP-332 is a small-molecule ERRα agonist with remarkable endurance, fat oxidation, and mitochondrial benefits. Here's the complete guide to what it does, who it's for, and how to use it.
PeptIQ Research Team
Editorial
PeptIQ app
Log your dosing protocol in PeptIQ
Turn this guide into a living protocol — doses, vials, and history in one place.
# SLU-PP-332: The ERRα Agonist That Gives You the Benefits of Exercise in a Vial
SLU-PP-332 is unlike most compounds in the biohacking world. It's not a peptide — it's a small synthetic molecule that activates estrogen-related receptor alpha (ERRα), one of the master regulators of mitochondrial biogenesis and fat metabolism. In animal studies, it produced dramatic improvements in endurance capacity without any additional training.
What Is SLU-PP-332?
SLU-PP-332 was developed by researchers at Scripps Research. ERRα is a transcription factor that regulates genes controlling:
Mitochondrial biogenesis — building new mitochondria
Oxidative phosphorylation — how efficiently cells produce ATP
Fatty acid oxidation — how much fat gets burned for fuel
Muscle fiber type switching — shifting toward slow-twitch oxidative fibers
How SLU-PP-332 Works
SLU-PP-332 binds to ERRα's ligand-binding domain and increases its transcriptional activity.
Downstream effects:
Upregulates PGC-1α — the primary driver of mitochondrial biogenesis
Increases expression of genes for beta-oxidation
Promotes type I (slow-twitch) muscle fiber characteristics
Reduces visceral fat mass
Improves insulin sensitivity
Dosing Protocol
Standard oral dosing:
Starting dose: 5mg/day oral
Effective range: 10–25mg/day
Frequency: Daily or 5 days on/2 days off
Cycle length: 4–8 weeks
Timing: Morning fasted
Stack Combinations
The Mitochondrial Triple Stack:
SLU-PP-332 10–15mg/day oral (ERRα → biogenesis)
MOTS-C 500mcg/day subQ (AMPK → function)
SS-31 0.5mg/day subQ (cardiolipin → protection)
Fat Loss Augmentation with GLP-1:
Retatrutide 1–3mg/week
SLU-PP-332 10mg/day oral
AOD-9604 300mcg/day fasted subQ
Track Your Metabolic Stack
Running SLU-PP-332 alongside GLP-1s, MOTS-C, or SS-31? PeptIQ helps you track energy, recovery, body composition, and protocol adherence across your full stack.
