Back to Research & Science
Research & Science••9 min read

SLU-PP-332: The ERRα Agonist That Gives You the Benefits of Exercise in a Vial

SLU-PP-332 is a small-molecule ERRα agonist with remarkable endurance, fat oxidation, and mitochondrial benefits. Here's the complete guide to what it does, who it's for, and how to use it.

PeptIQ Research Team
Editorial
SLU-PP-332: The ERRα Agonist That Gives You the Benefits of Exercise in a Vial

PeptIQ app

Log your dosing protocol in PeptIQ

Turn this your peptides guide into a living protocol — doses, vials, and history in one place.

Track this protocolOpen web app

iOS, Android, and web

Tools for this page

Ask PeptIQ

Two taps on our guided quiz, then keep going in iMessage with sources — not Instagram screenshots.

Start the quizOr try Peptide X Quiz →

# SLU-PP-332: The ERRα Agonist That Gives You the Benefits of Exercise in a Vial

SLU-PP-332 is unlike most compounds in the biohacking world. It's not a peptide — it's a small synthetic molecule that activates estrogen-related receptor alpha (ERRα), one of the master regulators of mitochondrial biogenesis and fat metabolism. In animal studies, it produced dramatic improvements in endurance capacity without any additional training.

What Is SLU-PP-332?

SLU-PP-332 was developed by researchers at Scripps Research. ERRα is a transcription factor that regulates genes controlling:

  • Mitochondrial biogenesis — building new mitochondria
  • Oxidative phosphorylation — how efficiently cells produce ATP
  • Fatty acid oxidation — how much fat gets burned for fuel
  • Muscle fiber type switching — shifting toward slow-twitch oxidative fibers

How SLU-PP-332 Works

SLU-PP-332 binds to ERRα's ligand-binding domain and increases its transcriptional activity.

Downstream effects:

  • Upregulates PGC-1α — the primary driver of mitochondrial biogenesis
  • Increases expression of genes for beta-oxidation
  • Promotes type I (slow-twitch) muscle fiber characteristics
  • Reduces visceral fat mass
  • Improves insulin sensitivity

Dosing Protocol

Standard oral dosing:

  • Starting dose: 5mg/day oral
  • Effective range: 10–25mg/day
  • Frequency: Daily or 5 days on/2 days off
  • Cycle length: 4–8 weeks
  • Timing: Morning fasted

Stack Combinations

The Mitochondrial Triple Stack:

  • SLU-PP-332 10–15mg/day oral (ERRα → biogenesis)
  • MOTS-C 500mcg/day subQ (AMPK → function)
  • SS-31 0.5mg/day subQ (cardiolipin → protection)

Fat Loss Augmentation with GLP-1:

  • Retatrutide 1–3mg/week
  • SLU-PP-332 10mg/day oral
  • AOD-9604 300mcg/day fasted subQ

Track Your Metabolic Stack

Running SLU-PP-332 alongside GLP-1s, MOTS-C, or SS-31? PeptIQ helps you track energy, recovery, body composition, and protocol adherence across your full stack.

Download PeptIQ

Related topics

Mitochondria
Share this article
TwitterLinkedIn

Track Your Peptide Protocols

Use PeptIQ to log injections, calculate doses, access our peptide library, and optimize your protocols.

Download PeptIQ

Stay ahead of the peptide conversation

Weekly-ish notes on new research, wiki trends, and practical tracking tips. No spam — unsubscribe anytime.

Educational updates only — not medical advice. Privacy

Explore More Peptide Resources

Free peptide calculators·Peptide research hub·Peptide glossary·Semaglutide guide·BPC-157 guide·Best peptide calculator

Related Articles

Selank and Semax: The Complete Protocol for Calm Focus and Cognitive Enhancement
8 min read

Selank and Semax: The Complete Protocol for Calm Focus and Cognitive Enhancement

Peptides for Psoriasis and Autoimmune Skin Conditions: What the Research Shows
9 min read

Peptides for Psoriasis and Autoimmune Skin Conditions: What the Research Shows

CJC-1295 With DAC vs Without DAC: What's the Difference and Which Should You Use?
9 min read

CJC-1295 With DAC vs Without DAC: What's the Difference and Which Should You Use?

More in Research & Science