# Selank and Semax: The Complete Protocol for Calm Focus and Cognitive Enhancement
Selank and Semax are two of the most studied nootropic peptides in the Russian pharmacological research tradition — and they've earned a dedicated following in the biohacking community for good reason. They're both intranasal, fast-acting, and well-tolerated. But they do very different things, which is why the question of how to use them together matters.
This guide covers both compounds individually, then explains the best protocols for combining them.
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What Is Semax?
Semax is a synthetic heptapeptide derived from ACTH (adrenocorticotropic hormone). It was developed in Russia in the 1980s and is registered as a pharmaceutical there for stroke recovery, cognitive impairment, and ADHD.
Mechanism of action:
- Increases BDNF and NGF expression
- Upregulates dopaminergic and serotonergic signaling
- Modulates the HPA axis (stress response)
- Enhances working memory and attention via prefrontal cortex activity
- Modulates GABA-A receptor activity
- Regulates enkephalins and endorphins
- Increases BDNF expression
- Downregulates stress-response hyperactivation in the amygdala
- Semax: 100–200mcg per dose
- Selank: 250mcg per dose
- Timing: 5–15 minutes before starting work
- Morning: Semax 200–300mcg
- Evening: Selank 250–500mcg
- Semax before high-stakes work or creative sessions
- Selank before stressful events or on high-anxiety days
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What Is Selank?
Selank is a synthetic hexapeptide derived from Tuftsin. Also developed in Russia, where it's registered as an anxiolytic and nootropic.
Mechanism of action:
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Semax vs. Selank: Core Difference
Semax sharpens. Selank calms. Run together, they create a "calm focus" state that many people find more effective than either alone.
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Protocol Options
Option 1: Stack Together (AM — Calm Focus)
Option 2: Split AM/PM
Option 3: Situational Use
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Track Your Cognitive Stack
The best way to know if Selank and Semax are working for you is to track it. PeptIQ lets you log mood, focus, energy, and sleep quality so you can see the actual impact of your nootropic protocol over time.
