PubMed
An NNMT inhibitor activates oxidative metabolism and reduces obesity in mice
Neelakantan H, Vance V, Wang H, et al. Nat Commun. 2019
Compare
5-Amino-1MQ vs Pentosan Polysulfate
Side-by-side observational reports from PeptIQ users. This compares self-reported patterns — not clinical head-to-head trials.
Last reviewed . By the PeptIQ team.
Observational reporting only — not medical advice. Does not recommend doses, protocols, or treatments.
5-Amino-1MQ
43 community reports
Overall experience
From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Favorable 94% · Mixed 6% · Unfavorable overall 0%
Most reported benefits
Benefits users selected when logging a favorable or mixed check-in.
Appetite
158
Recovery
158
Most logged side effects
Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Nausea
9
Self-reported dose per injection
Median bucket: 5+ mg · Most common: 5+ mg
Reports span 0.2 to ≥ 5 mg (open-ended top bucket)
0.2–0.4 mg
1
0.4–0.6 mg
2
1–2 mg
21
5+ mg
134
Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.
Commonly stacked with
How repeat users are trending
Among repeat reporters, 86% said they felt similar to their last entry, 14% more positive, and 0% more negative.
Overall, repeat reporters leaned more positive than their previous entry.
Median gap between entries: 86 days · Based on 28 repeat reporters
Pentosan Polysulfate
6 community reports
Overall experience
From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Favorable 0% · Mixed 17% · Unfavorable overall 83%
Most reported benefits
Benefits users selected when logging a favorable or mixed check-in.
Recovery
6
Most logged side effects
Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Digestive upset
6
Self-reported dose per injection
Median bucket: 0–25 mcg · Most common: 0–25 mcg
Reports cluster around 0–25 mcg
0–25
6
Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.
Commonly stacked with
Sources (7)
Published sources linked on the 5-Amino-1MQ and Pentosan Polysulfate wiki pages.
- Wiki study page →Source
- Wiki study page →Source
PubMed
NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity
Heide J, Bilecz AJ, Patnaik S, et al. Nature. 2025
- Wiki study page →Source
PubMed
Exploring NNMT: from metabolic pathways to therapeutic targets
Park J, Shin EJ, Kim TH, et al. Archives of pharmacal research. 2024
- Wiki study page →Source
FDA Drug Label
ELMIRON (pentosan polysulfate sodium) — Prescribing Information
Janssen Pharmaceuticals. FDA Drug Label. 1996
- Wiki study page →Source
PubMed
Pentosan polysulfate sodium for knee osteoarthritis: systematic review
Bannuru RR, Osani MC, Vaysbrot EE, et al. Osteoarthritis Cartilage. 2020
- Wiki study page →Source
PubMed
New therapeutic strategies in osteoarthritis
Siddiq MAB, Oo WM, Hunter DJ. Joint bone spine. 2024
- Wiki study page →Source
PubMed
The pathobiology of osteoarthritis and the rationale for the use of pentosan polysulfate for its treatment
Ghosh P. Seminars in arthritis and rheumatism. 1999