# Orforglipron Dosing Guide: Oral GLP-1 Titration to 6, 12, and 36 mg
> Note: PeptIQ is not a medical provider. Orforglipron is an investigational oral GLP-1 receptor agonist. Doses reflect Phase 3 trial designs and public disclosures — not a prescription.
Orforglipron (LY3502970) is the oral GLP-1 story people keep comparing to injectable semaglutide and tirzepatide — and to oral semaglutide's awkward fasting rules. It is a once-daily small-molecule GLP-1 receptor agonist taken as a capsule, without the food-and-water gymnastics Rybelsus requires.
Quick Answer: Orforglipron Dosage
| Phase | Dose pattern |
|---|---|
| Start | 1 mg once daily |
| Escalation | Step up about every 4 weeks |
| Obesity maintenance (ATTAIN-1) | 6 mg, 12 mg, or 36 mg once daily |
| Diabetes example (ACHIEVE-1) | Maintenance arms including 3 mg, 12 mg, 36 mg in public descriptions |
ATTAIN-1 Titration Ladder (Obesity)
ATTAIN-1 (NCT05869903) was a 72-week Phase 3 trial in adults with obesity or overweight plus comorbidity, without diabetes. Participants started at 1 mg daily and escalated at four-week intervals to their randomized maintenance dose:
| Target maintenance | Typical step path described publicly |
|---|---|
| 6 mg | 1 mg → 3 mg → 6 mg |
| 12 mg | 1 mg → 3 mg → 6 mg → 12 mg |
| 36 mg | 1 mg → 3 mg → 6 mg → 12 mg → 24 mg → 36 mg |
Dose reductions were generally reserved for GI tolerability after other mitigations failed (per public trial descriptions).
Weight-Loss Results People Cite
Public ATTAIN-1 summaries (efficacy-style figures) reported roughly:
| Arm | Approx. mean weight change @ 72 weeks |
|---|---|
| 6 mg | ~−8% |
| 12 mg | ~−9% |
| 36 mg | ~−12% |
| Placebo | ~−1% |
Treatment-policy / other estimands in media coverage sometimes quote slightly different percentages (for example ~7.5–11% ranges). Prefer the NEJM table for citations. Directionally: higher maintenance dose → larger mean loss, with classic GLP-1 GI adverse events.
Why Oral Dosing Changes Tracking
Injectable weekly drugs create a "dose day" narrative. Orforglipron is daily, which means:
