# Ipamorelin Reconstitution and Dosing: Selective GH Secretagogue Context
> Note: PeptIQ is not a medical provider. This article is educational only. It is not a protocol.
Ipamorelin is a pentapeptide growth hormone secretagogue that acts at the ghrelin receptor (GHSR-1a). Raun and colleagues described it as a selective GH secretagogue in 1998 (PubMed 9849822). A later clinical endocrinology paper discussed ipamorelin as a GH-releasing peptide in human research contexts (PubMed 11174832). ClinicalTrials.gov indexes ipamorelin GH studies (search).
Selectivity in those papers means a cleaner GH pulse relative to some older GHRPs in the models studied. It does not mean a consumer vial is standardized, indicated, or dosed.
Evidence tier
| Layer | Use | Limit |
|---|
| 1998–2001 secretagogue papers | Receptor selectivity and GH-release pharmacology | Not a reconstitution chart |
| GHRH plus GHRP synergy literature | Why people discuss pairing with a GHRH analog | Not a stack prescription |
| Community and in-app logs | Microgram habits people record | Observational |
Lyophilized-vial math
Educational summaries treat ipamorelin like other freeze-dried research peptides:
Concentration (mcg/mL) = (vial mg × 1,000) ÷ diluent mL
Volume (mL) = desired mcg ÷ concentration
Illustrative example only
A vial labeled 5 mg with 2 mL bacteriostatic water is 2,500 mcg/mL. A 200 mcg discussion figure would be 0.08 mL (8 units on a U-100 syringe). A 300 mcg figure would be 0.12 mL (12 units). A 2 mg vial with 2 mL is 1,000 mcg/mL, so 200 mcg is 0.20 mL (20 units).
Small-unit draws are easy to misread. That is a math caution, not a mixing instruction.
Bacteriostatic water is the diluent named most often for multi-draw vials. Growth-hormone secretagogues are frequently described as more fragile than copper peptides or GLP-1 solutions when mixed in one syringe. Separate reconstitution vials are the conservative educational default. Refrigeration after reconstitution is the usual storage claim.
Research-reference ranges
Early papers used study-specific parenteral doses to measure GH pulses, not a nightly 200–300 mcg consumer ritual. Community tables still cluster in that low-hundreds-of-micrograms band, often once daily or a few times per day, sometimes timed to sleep or training in anecdotal write-ups.
PeptIQ users who log ipamorelin often record it in the same session as CJC-1295 or another GHRH analog. That pairing tracks the synergy literature at a slogan level. It does not validate a milligram chart.
| Source | Figure | Reading |
|---|
| Raun 1998 / Johansen 2001 lineage | Pharmacology and GH release in research settings | Not a home protocol |
| Community tables | 200–300 mcg per administration, variable frequency | Uncontrolled habit |
| In-app logs | Frequent pairing with a GHRH analog | Observational stack |
Cortisol and prolactin sparing is a talking point copied from older comparative GHRP papers. Treat it as a relative pharmacology claim from specific experiments, not a guarantee for an unlabeled vial.
Route language
Published and community sources discuss subcutaneous administration. Timing narratives (evening, fasted, peri-training) are behavioral folklore layered on a short-acting secretagogue story. They are not instructions. Administration technique is out of scope.
See the CJC-1295 plus ipamorelin stack guide for combination context, and the new CJC-1295 reconstitution page for the GHRH-analog half-life split.
Bottom line
Ipamorelin has a real selective-secretagogue literature. Reconstitution math is generic. Microgram tables are community conventions. Pairing with a GHRH analog is a pharmacology talking point, not a prescription.
