Sexual HealthLimited ResearchCaution: Indication-Specific Approval

Melanotan I

Afamelanotide-related

Not medical advice. For educational and research reference only.

Typical Dose

Varies by protocol

Route

Injectable / Implant

Cycle

Specialist-managed

Storage

2–8°C Refrigerated

What is Melanotan I?

Alpha-MSH analog related to afamelanotide pathways; non-indicated tanning use carries risk.

Research Indications

Sexual FunctionEffective

Research and clinical data supporting effects on sexual response

Libido SupportEffective

Clinical data shows improvements in desire and arousal metrics

Melanocortin ActivityModerate

Acts via central nervous system melanocortin receptor pathways

Research Protocols

These are commonly discussed research protocols — not medical advice. Consult a healthcare provider before use.

GoalDoseFrequencyRoute
Starting DoseLow dosePer protocolVaries
Standard DoseTitratedPer protocolVaries

Peptide & Drug Interactions

Always consult your healthcare provider before combining with other compounds. Use our Interaction Checker for reference.

PDE5 Inhibitors (Sildenafil, Tadalafil)Monitor
Blood Pressure MedicationsCaution
Other Melanocortin AgonistsAvoid
NaltrexoneMonitor

How to Reconstitute & Inject

Use bacteriostatic (BAC) water only. Avoid saline — may cause precipitation. Refrigerate and use within 28 days.

  1. 1

    Remove Melanotan I vial from refrigeration and allow to reach room temperature (15–20 minutes)

  2. 2

    Clean vial top with alcohol swab and allow to air dry completely

  3. 3

    Using a sterile syringe, draw the calculated volume of bacteriostatic water (BAC water)

  4. 4

    Inject BAC water slowly down the side of the vial — do not aim directly at the powder

  5. 5

    Gently swirl in circular motions — DO NOT shake vigorously as this degrades the peptide

  6. 6

    Allow 2–3 minutes for full dissolution — solution should be clear and colorless

  7. 7

    Draw calculated dose into an insulin syringe for subcutaneous injection

  8. 8

    Inject into abdomen, thigh, or upper arm. Rotate injection sites to prevent lipodystrophy

  9. 9

    Store reconstituted solution refrigerated (2–8°C) and use within 28 days

What to Expect

Week 1–2

Initial effects and adaptation period. Monitor for any adverse reactions.

Week 2–4

Primary effects begin to manifest. Adjust dosing as recommended by your provider.

Week 4–8

Main therapeutic effects should be established. Assess progress with your provider.

Week 8+

Evaluate results and determine continuation, cycling, or dose adjustments.

Side Effects & Safety

  • Injection site reactions (redness, bruising, mild pain)
  • Potential for allergic reaction — discontinue if rash or hives occur
  • Individual reactions vary — start at the lowest dose and monitor carefully
  • Consult your healthcare provider before use and report any unusual symptoms

FDA Status & Regulatory Info

Caution: Indication-Specific Approval

Alpha-MSH analog related to afamelanotide pathways; non-indicated tanning use carries risk.

Rx Required: Yes
503A Ban: No
Telehealth: N/A
Full FDA Status Tracker

Frequently Asked Questions

Research References

External links for education only. We do not control third-party content.

Research purposes only

This page is for educational reference. It is not medical or legal advice. Consult the FDA and a licensed healthcare professional for current regulations and individualized guidance.