What is Follistatin 344?
Follistatin 344 is an isoform of follistatin (FST), a naturally occurring glycoprotein that binds and neutralizes TGF-β superfamily members, most notably myostatin (GDF-8) and activin A. Animal studies show dramatic and permanent muscle hypertrophy with single gene therapy doses. Human pharmacokinetic and safety data are extremely limited; the risk of irreversible muscular hypertrophy and unknown off-target effects make this highly experimental. Research only — extreme caution advised.
Mechanism of Action
High-affinity binding and sequestration of myostatin (GDF-8), activin A, and activin B; relieves myostatin-mediated inhibition of muscle satellite cell activation; allows unrestricted muscle fiber hypertrophy and hyperplasia
Target: Myostatin (GDF-8), Activin A, Activin B, BMP-11
Research Indications
Demonstrated acceleration of wound healing and soft tissue repair in research
Research shows beneficial effects on intestinal lining and GI function
Associated with reduced joint inflammation and improved mobility
May support faster recovery from muscle strains and exercise stress
Research Protocols
These are commonly discussed research protocols — not medical advice. Consult a healthcare provider before use.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Starting Dose | 100 mcg | Once daily | Subcutaneous injection |
| Standard Dose | 250 mcg | Once daily | Subcutaneous injection |
Peptide & Drug Interactions
Always consult your healthcare provider before combining with other compounds. Use our Interaction Checker for reference.
How to Reconstitute & Inject
Use bacteriostatic (BAC) water only. Avoid saline — may cause precipitation. Refrigerate and use within 28 days.
- 1
Remove Follistatin 344 vial from refrigeration and allow to reach room temperature (15–20 minutes)
- 2
Clean vial top with alcohol swab and allow to air dry completely
- 3
Using a sterile syringe, draw the calculated volume of bacteriostatic water (BAC water)
- 4
Inject BAC water slowly down the side of the vial — do not aim directly at the powder
- 5
Gently swirl in circular motions — DO NOT shake vigorously as this degrades the peptide
- 6
Allow 2–3 minutes for full dissolution — solution should be clear and colorless
- 7
Draw calculated dose into an insulin syringe for subcutaneous injection
- 8
Inject into abdomen, thigh, or upper arm. Rotate injection sites to prevent lipodystrophy
- 9
Store reconstituted solution refrigerated (2–8°C) and use within 28 days
What to Expect
Week 1–2
Initial anti-inflammatory effects begin. Reduced pain and swelling in target area.
Week 2–4
Improved tissue mobility and reduced discomfort. Early healing acceleration.
Week 4–8
Significant recovery milestones. Stronger tissue repair and functional improvement.
Week 8–12
Near-complete healing in many cases. Improved strength and tissue integrity.
Side Effects & Safety
- Generally well-tolerated in research settings
- Mild nausea with higher doses
- Injection site redness or discomfort
- Rare: Dizziness or lightheadedness
- Potential effect on blood pressure (monitor if hypertensive)
FDA Status & Regulatory Info
Follistatin 344 is an isoform of follistatin (FST), a naturally occurring glycoprotein that binds and neutralizes TGF-β superfamily members, most notably myostatin (GDF-8) and activin A. Animal studies show dramatic and permanent muscle hypertrophy with single gene therapy doses. Human pharmacokinetic and safety data are extremely limited; the risk of irreversible muscular hypertrophy and unknown off-target effects make this highly experimental. Research only — extreme caution advised.
Frequently Asked Questions
Research References
External links for education only. We do not control third-party content.
Community-reported data
The information below reflects self-reported experiences from PeptIQ app users. It is not clinical evidence and should not replace professional medical advice.
Community Intelligence
What 6 users report
Positive 100% · Neutral 0% · Negative 0%
Most reported benefits
Dose distribution
Median: 50–100 mcg · Most common: 50–100 mcg
Commonly stacked with
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Rate Follistatin 344 in the PeptIQ app and help the community make informed decisions.
Research purposes only
This page is for educational reference. It is not medical or legal advice. Consult the FDA and a licensed healthcare professional for current regulations and individualized guidance.