What is Humanin?
Humanin is a 21-amino acid mitochondria-derived peptide encoded within the 16S rRNA region of the mitochondrial genome, discovered in 2001 from a cDNA library of Alzheimer's-resistant brain tissue. Research demonstrates neuroprotective, anti-apoptotic, and metabolic effects. Circulating humanin levels decline significantly with aging. Studied for Alzheimer's disease, diabetes, and cardiovascular protection. Research only.
Mechanism of Action
Binding to CNTFR/WSX-1/gp130 receptor complex activating JAK2/STAT3; direct inhibition of Bax-mediated apoptosis in neurons; insulin sensitization via IGF-1 receptor interaction; anti-inflammatory via NF-κB suppression
Target: CNTFR/WSX-1/gp130 complex, Bax, IGF-1 receptor
Research Indications
Research supports improvements in mitochondrial bioenergetics and ATP production
May improve insulin sensitivity and glucose metabolism
Early research suggests potential effects on cellular aging markers
Research Protocols
These are commonly discussed research protocols — not medical advice. Consult a healthcare provider before use.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Starting Dose | Low dose | Per protocol | Varies |
| Standard Dose | Titrated | Per protocol | Varies |
Peptide & Drug Interactions
Always consult your healthcare provider before combining with other compounds. Use our Interaction Checker for reference.
How to Reconstitute & Inject
Use bacteriostatic (BAC) water only. Avoid saline — may cause precipitation. Refrigerate and use within 28 days.
- 1
Remove Humanin vial from refrigeration and allow to reach room temperature (15–20 minutes)
- 2
Clean vial top with alcohol swab and allow to air dry completely
- 3
Using a sterile syringe, draw the calculated volume of bacteriostatic water (BAC water)
- 4
Inject BAC water slowly down the side of the vial — do not aim directly at the powder
- 5
Gently swirl in circular motions — DO NOT shake vigorously as this degrades the peptide
- 6
Allow 2–3 minutes for full dissolution — solution should be clear and colorless
- 7
Draw calculated dose into an insulin syringe for subcutaneous injection
- 8
Inject into abdomen, thigh, or upper arm. Rotate injection sites to prevent lipodystrophy
- 9
Store reconstituted solution refrigerated (2–8°C) and use within 28 days
What to Expect
Week 1–2
Initial effects and adaptation period. Monitor for any adverse reactions.
Week 2–4
Primary effects begin to manifest. Adjust dosing as recommended by your provider.
Week 4–8
Main therapeutic effects should be established. Assess progress with your provider.
Week 8+
Evaluate results and determine continuation, cycling, or dose adjustments.
Side Effects & Safety
- Injection site reactions (redness, bruising, mild pain)
- Potential for allergic reaction — discontinue if rash or hives occur
- Individual reactions vary — start at the lowest dose and monitor carefully
- Consult your healthcare provider before use and report any unusual symptoms
FDA Status & Regulatory Info
Humanin is a 21-amino acid mitochondria-derived peptide encoded within the 16S rRNA region of the mitochondrial genome, discovered in 2001 from a cDNA library of Alzheimer's-resistant brain tissue. Research demonstrates neuroprotective, anti-apoptotic, and metabolic effects. Circulating humanin levels decline significantly with aging. Studied for Alzheimer's disease, diabetes, and cardiovascular protection. Research only.
Frequently Asked Questions
Research References
External links for education only. We do not control third-party content.
Community-reported data
The information below reflects self-reported experiences from PeptIQ app users. It is not clinical evidence and should not replace professional medical advice.
Community Intelligence
What 6 users report
Positive 100% · Neutral 0% · Negative 0%
Most reported benefits
Dose distribution
Median: 2000+ mcg · Most common: 2000+ mcg
Commonly stacked with
Share Your Experience
Rate Humanin in the PeptIQ app and help the community make informed decisions.
Research purposes only
This page is for educational reference. It is not medical or legal advice. Consult the FDA and a licensed healthcare professional for current regulations and individualized guidance.