cids you want and biology will still tear apart your muscle, because the signal driving the breakdown isn’t from low amino acidsthe signal is that biology is in an energy scarcity, and it’s firing up the catabolic reactor… I’ll explain it and solve it for you And I’ll put the exact protocol for muscle preservation on GLP1s in the research and in my stories later today You’re welcome Comment “MUSCLE” for the research playbook Never Miss Dr Trevor Bachmeyer The Spartan #health #muscle #doctor #nevermiss #thespartan Medical Disclaimer: The contents of this video & other material are intended for entertainment, informational & educational purposes only & not for the purpose of rendering medical advice, always seek the advice of a health professional

When it's turned off, biology is catabolic, period. Tapping GLP-1 receptors mimics a fasting state. Biology thinks that calories are limited and the nervous system goes into a metabolic defense mode. In a caloric deficit, especially a severe one like on GLP-1s, biology breaks down muscle tissue through a process called the ubiquitin proteasome pathway or UPP. It's designed to recycle amino acids from muscle to keep the brain, the heart, and the immune system functioning properly. Here's the Cliff Notes version. Enzymes tag muscle proteins with ubiquitin. It's like putting a giant red sticker on a package. Proteasomes see the tags and then they chew up the muscle protein into amino acids, which head to the liver for gluconeogenesis to make glucose to feed your starving brain. This entire process is independent of protein intake and Insta bros and doctors and Insta experts will argue, just eat more protein, problem solved. Wrong. I'll even show you how, and I'll solve it for you. Yes, protein intake matters for providing amino acid substrate for muscle protein synthesis. You can have all the amino acids you want and the UPP will still tear apart your muscle because the signal driving the breakdown isn't low amino acids. The signal is biology is in energy scarcity, fire up the catabolic reactor. So when you're on GLP-1s, especially semaglutide or terzapatide, don't get mad. The nervous system is saying the opposite. It's saying danger, crank up the UPP and recycle all the muscle for energy. Protein provides the raw materials, but the nuclear meltdown needs to be shut down. And the meltdown is the ubiquitin proteasome pathway, which requires very specific biochemical interventions. Let me show you. The UPP has specific regulatory points that can easily be handled with three amino acids, leucine, isoleucine, and valine, and then collagen peptides. So leucine is designed to wake up mTOR. Isoleucine suppresses something called hypoxia-inducible factor alpha-1, which normally cranks up autophagy and the UPP, and branched-chain amino acids won't circulate properly without valine. So five grams of leucine, three grams of isoleucine, three grams of valine per day, split over three doses. It's the old school two one one ratio. Any eighties meathead will know exactly what I'm talking about. And then add 20 grams of hydrolyzed collagen peptides per day, not intact collagen. So not powder, not bone broth, because they're giant proteins that get broken down like every other protein and won't trip the signal that you need. I'll put the exact protocol for muscle preservation on GLP ones in the research and in my stories later today or tomorrow. You're welcome. Comment muscle for the research playbook. I've got to go. Never miss.